Abstract
Copper (II) complexes of Schiff bases derived from [1 + 1] condensation of salicylaldehyde, 2,3-dihydroxybenzaldehyde and 2,3,4-trihydroxybenzaldehyde with anthranilic acid ( L 1 – L 3 ) have been synthesized and characterized by elemental analyses, IR, UV–Vis spectra, room temperature magnetic susceptibility, electron paramagnetic resonance spectroscopy and cyclic voltammetry. The X-ray structure of [Cu L 1 ] n has been solved and refined to R = 0.0314. The crystals are monoclinic with space group P2 1 with cell constants a = 9.6820(13), b = 7.1446(11), c = 9.9315(13) Å, β = 98.385(8)°, Z = 2. The copper (II) ions are in a distorted tetrahedral environment sequentially bridged by carboxylate groups in the syn– anti conformation giving rise to a helix-like chain. The copper complexes with the inherent redox active hydroquinone functionality cleave plasmid pBR322 DNA without exogenous agents by a self-activating mechanism.
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