Abstract
A self-assembled unilamellar vesicle, which can be used as a drug delivery system, was easily and simply fabricated using a blended system of Pluronic block copolymers. Controlling the hydrophilic mass fraction of block copolymers (by blending the block copolymer with a different hydrophilic mass fraction) and temperature (i.e., the hydrophobic interaction is controlled), a vesicular structure was formed. Small angle neutron scattering measurements showed that the vesicular structure had diameters of empty cores from 13.6 nm to 79.6 nm, and thicknesses of the bilayers from 2.2 nm to 8.7 nm when the hydrophobic interaction was changed. Therefore, considering that the temperature of the vesicle formation is controllable by the concentration of the blended block copolymers, it is possible for them to be applied in a wide range of potential applications, for example, as nanoreactors and nanovehicles.
Highlights
Since the 1990s, many studies have been conducted to investigate methods of manufacturing drug carriers using various types of nanomaterials
A method to control the phases of polymeric micelles using an easy and simple
F127 triblock copolymer exists as a random coil and spherical micelle.was
Summary
Since the 1990s, many studies have been conducted to investigate methods of manufacturing drug carriers using various types of nanomaterials. Pluronic block copolymers undergo different phase transitions depending on the temperature and are controlled, which can provide many self-assembled structures that are applicable for drug delivery. Considering that it is necessary for a drug transporter to have temperature sensitivity in the body, Pluronic block copolymers are able to be used as a human drug delivery system. Block and the Poly(Propylene Oxide) (PPO) block, the specific temperature range for forming micellar structures is controlled by changing their mass fractions, which may provide a functional drug delivery vehicle with temperature sensitivity. Upon controlling the mass fraction of the PEO block and the PPO block, we can expect different phase behaviors of block copolymers, providing various types of structures for drug delivery systems. This study can provide an easy method to fabricate the spontaneous unilamellar polymeric vesicles in an aqueous solution without complicated procedures
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