Self-Assembly Evolution of N-Terminal Aromatic Amino Acids with Transient Supramolecular Chirality.

Abstract

Deep understanding and fine tailoring of spontaneous structural evolution of self-assembled arrays are pivotal in the rational design of advanced soft materials. However, an indistinct structure-property relationship and pathway complexity in self-assembly lead to a considerable challenge. Herein, we reveal the self-assembly pathway complexity in spontaneous aggregation of several N-terminated aromatic amino acids. By primarily tuning the incubation time, building blocks appended with alanine and serine selectively form 1:1 hydrated clathrates, enabling the microfiber to transition to crystals. The dynamic water intercalation process was studied by incubation time-dependent morphological changes, powder X-ray diffraction, and single-crystal structure analysis. A pronounced amino acid residue effect on the self-assembly evolution was reflected by supramolecular chirality inversion of the building block having the phenylalanine residue, accomplishing dynamic M- to P-helicity transition within a confined time scale.