Self-Assembly and Multifaceted Bioactivity of a Silver(I) Quinolinate Coordination Polymer.

Sabina W Jaros,Urszula Śliwińska-Hill,Dominik Poradowski,Piotr Smoleński,Magdalena Florek,Alexander M Kirillov,Barbara Bażanów,Dmytro S Nesterov,Agnieszka Krogul-Sobczak

doi:10.1021/acs.inorgchem.1c02110

Abstract

Coordination polymers have emerged as a new class of potent biologically active agents due to a variety of important characteristics such as the presence of bioactive metal centers and linkers, low toxicity, stability, tailorable structures, and bioavailability. The research on intermediate metabolites has also been explored with implications toward the development of selective anticancer, antimicrobial, and antiviral therapeutic strategies. In particular, quinolinic acid (H2quin) is a recognized metabolite in kynurenine pathway and potent neurotoxic molecule, which has been selected in this study as a bioactive building block for assembling a new silver(I) coordination polymer, [Ag(Hquin)(μ-PTA)]n·H2O (1). This product has been prepared from silver oxide, H2quin, and 1,3,5-triaza-7-phosphaadamantane (PTA), and fully characterized by standard methods including single-crystal X-ray diffraction. Compound 1 has revealed distinctive bioactive features, namely (i) a remarkable antiviral activity against herpes simplex virus type 1 (HSV-1) and adenovirus 36 (Ad-36), (ii) a significant antibacterial activity against clinically important bacteria (Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa), and (iii) a selective cytotoxicity against HeLa (human cervix carcinoma) cell line. The present work widens a growing family of bioactive coordination polymers with potent antiviral, antibacterial, and antiproliferative activity.

Highlights

Infectious diseases and those of a viral genesis are responsible for igniting most of the global pandemics
(I)-based compounds with potent and diverse bioactivity were reported in our previous studies.[33−40] Within this context and following our major goal in exploring the chemistry and biofunctional applications of silver−PTA coordination polymers, we report the self-assembly synthesis, characterization, spectroscopic and structural features, and antiviral, antimicrobial, and antiproliferative properties of a new silver(I)
By combination of biocidal metal nodes and water-soluble aminophosphine linker with quinolinate(1−) ligand as an important metabolic intermediate, the present compound extends the family of bioactive silver(I) coordination polymers

Summary

■ INTRODUCTION

Infectious diseases and those of a viral genesis are responsible for igniting most of the global pandemics. A more intense band at 209 nm and a broad and weak band around 221 nm can be assigned to α-helical structure and π → π*/n → π* transitions for the peptide bond, respectively.[56] Under the experimental conditions, 1 does not generate the CD signal, but as evident from Figure S14, the presence of the silver compound has an effect on the secondary structure of the albumin, causing some changes in the intensity of the protein negative band at 209 nm. The band intensities of HSA at 209 and 221 nm decreased with the negative Cotton effect through the binding of 1 without causing significant shifts of the peaks, clearly indicating that the compound induced a slight decrease in the α-helical structure content of the protein. It is evident that the effect of 1 on HSA caused secondary structural changes to the protein with a slight loss of the helical stability

■ CONCLUSIONS

■ ACKNOWLEDGMENTS

Findings

■ REFERENCES