Abstract
Natural products derived from plants play a significant role in drug discovery due to the revealing a large variety of pharmaceutical effects. Kickxia spuria was collected from Bingol, Turkey. Aerial parts of the plant were boiled in water for 2 h then extracted with ethyl acetate. After evaporation of the solvent by rotary evaporator, the extract was subjected to column chromatography to yield the compound identified as 6,7-dimethoxy-5-hydroxyflavone by spectroscopic method including 1D-, 2D-NMR, LC-TOF/MS. Antiproliferative activity of isolated compound was tested against HeLa (human cervix carcinoma) cell lines by xCELLigence assay, and found out that the compound exhibited excellent activity.
Highlights
Cancer, a destructive disease is a major public health burden in the world
Natural products derived from plants which have a strong activity against cancer cells could be an effective drugs for cancer treatment [2]
6,7-dimethoxy-5-hydroxyflavone was isolated from Kickxia spuria ethyl acetate extract and antiproliferative activity was investigated on human cervical cancer (HeLa) cell lines
Summary
A destructive disease is a major public health burden in the world. Developments in the treatment of cancer have resulted in the notable improved survival and quality of life for cancer patients lately. The major treatments for cancer contain chemotherapy, surgery and radiation therapy [1]. Therapeutic strategies and new drugs are continuously being researched and developed, current effect of chemotherapy is far from satisfactory. New approached should be developed for cancer treatment that have less side effects. Natural products derived from plants which have a strong activity against cancer cells could be an effective drugs for cancer treatment [2]. Kickxia species have been extensively used for traditional medicine to alleviate some diseases such as diuretic, against kidney stones, fever and rheumatism [7]. 6,7-dimethoxy-5-hydroxyflavone was isolated from Kickxia spuria ethyl acetate extract and antiproliferative activity was investigated on HeLa (human cervix carcinoma) cell lines. The isolated compound revealed the outstanding effect on this cell lines
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