Abstract
In recent years, the oxidative stress-induced free radicals have been implicated in the pathogenesis of type 1 diabetes mellitus (DM). It has been also reported that elements like selenium (Se), zinc (Zn), and copper (Cu) involved in lipid peroxidation may play a role in the pathogenesis and exacerbation of this disease. The aim of the present study was to evaluate the antioxidant status and micronutrient levels in children with type 1 DM. The study included 35 children with type 1 DM (16 girls and 19 boys) with a mean age of 13.8 ± 4.5 years and a mean disease duration of 3.6 ± 2.8 years and 26 age-matched healthy children (11 girls and 15 boys) with a mean age of 12.8 ± 3.3 years. The Se and Zn levels of children with type 1 DM were significantly lower than those of controls. Glycosylated hemoglobin (HbA1c) levels were found to be inversely correlated with Se and Zn levels. There was no any statistically significant difference between serum Cu levels of patients with type 1 DM and controls. Glutathione peroxidase (GSH-Px) levels were lower in patients with type 1 DM when compared with those of controls, and there was a negative correlation between HbA1c and GSH-Px levels. We believe that the increased oxidative stress may be originated from low levels of glutathione peroxidase resulted from decreased levels of Se. The negative correlation between Se, Zn, GSH-Px, and HbA1c levels may show poor metabolic control of the disease and effect of oxidative injury. Those elements should be closely monitored during the course of type 1 DM, and supplementation of these elements may be beneficial both for controlling diabetes and preventing long-term oxidative injury related to diabetic complications.
Published Version
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