Abstract
To evaluate the influence of tumor characteristics and irradiation on blood selenium concentrations and their course during radiotherapy. Selenium levels were determined at various times during radiotherapy (I: beginning, II: mid, III: end, IV: 6 weeks after) by atomic absorption spectrometry in whole blood. The values were correlated with patient-, tumor- and irradiation-related parameters. A total of 690 samples were analyzed in 224 patients. The mean selenium value was 75.64 μg/l at the beginning of radiotherapy. 170 patients (77%) had reduced selenium levels 0.05). A preexisting selenium deficiency could be diagnosed in the broad majority of cancer patients undergoing radiotherapy. In contrast to the widely held opinion, it was not further aggravated by standard radiotherapy protocols.
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