Abstract
AbstractSix 75Se labeled fatty acid analogues were synthesized : 3‐selena‐[75Se]pentadecanoic acid, 4‐selena[75Se]hexadecanoic acid, 3‐selena[75Se]heptadecanoic acid, 4‐selena[75Se]octadecanoic acid, 3‐selena[75Se]nonadecanoic acid, and 4‐selena[75Se]‐eicosanoic acid. Selenious acid was reduced with NaBH4 in buffer pH 6.0. The nucleophile produced, NaSeH was reacted with different alkyl halide to form the corresponding selenol. To this was added an aqueous solution of the sodium salt of either iodoacetic acid or 3‐bromopropionic acid to form the sodium salt of the desired fatty acid. The free fatty acids were extracted in ether after acidification of the solution.
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