Abstract
Pseudoallergic reactions to non-steroidal anti-inflammatory drugs (NSAID) are frequently occurring side-effects during the treatment of chronic pain conditions and non-infectious inflammation. The incidence is estimated to be 2%. In severe cases anaphylactoid reactions may develop. Patients suffering from this disease are therefore frequently transferred to allergologic units for diagnosis. Here, we review current insights into the pathomechanisms and treatment modalities of NSAID-intolerance. Especially, we address the use of new anti-inflammatory drugs with selective inhibition of the Cyclooxigenase II, since these drugs may have a lower risk of pseudo-allergic reactions in patients with NSAID-intolerance.
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