Abstract
A primer on new research by Fuentes-Medel and colleagues explains the important role of non-neural cells in clearing neural debris, which is continuously produced during the normal remodeling processes that establish and maintain neural connectivity.
Highlights
The nervous system is an intricately wired communication system that receives and responds to intrinsic and environmental information, allowing the organism to adapt to its surroundings
Mounting evidence shows that elimination processes are critical in shaping neural circuits during development as well as in regulating synaptic plasticity in response to experience and memory [3]
Several motor neurons send axons to the same muscle cell, so that one neuromuscular junction (NMJ) is innervated by axons from more than one motor neuron
Summary
The nervous system is an intricately wired communication system that receives and responds to intrinsic and environmental information, allowing the organism to adapt to its surroundings. These remodeling processes include the elimination of excess axons, dendrites, synapses, and their debris [2].
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