Abstract
Postsurgical ileus significantly increases morbidity and mortality. We have shown that intestinal manipulation initiates an intense molecular and cellular inflammatory response within the jejunal muscularis that causes ileus. The objective of this study was to investigate the molecular inflammatory responses in the stomach and colon initiated by selective small bowel manipulation and its functional significance.
Highlights
Postsurgical ileus significantly increases morbidity and mortality
We have shown that intestinal manipulation initiates an intense molecular and cellular inflammatory response within the jejunal muscularis that causes ileus
electrophoretic mobility shift assay (EMSA) for Stat3, the cytosolic messenger for IL-6 which promotes leukocyte infiltration showed a 4.8-fold increase in transcription factor activation in the jejunal bowel muscularis compared to a 3.8-fold increase in the gastric muscularis and an even higher 8.8-fold activation for Stat3 in the colonic muscularis
Summary
Postsurgical ileus significantly increases morbidity and mortality. We have shown that intestinal manipulation initiates an intense molecular and cellular inflammatory response within the jejunal muscularis that causes ileus. The objective of this study was to investigate the molecular inflammatory responses in the stomach and colon initiated by selective small bowel manipulation and its functional significance
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