Abstract
The effects of selective hepatic vagotomy on compensatory adjustments of feeding in response to experimentally induced changes in body weight were investigated in rats. Repeated injections of slow-acting insulin increased food intake and body weight in vagotomized as well as in sham-vagotomized rats. When the treatment was stopped, the rats of both surgical groups displayed a compensatory hypophagia of similar magnitude and body weight returned to preinjection levels. In turn, after 7 days of restricted feeding (5 g/day) with a concomitant loss of body weight, rats became hyperphagic and body weight approached the normal level. Again, the feeding responses or body weight changes did not differ between vagotomized and sham-vagotomized rats. The results demonstrate that selective hepatic vagotomy does not disrupt the putative feedback-loop between body weight and feeding, and raise questions concerning the role of the liver in the lipostatic control of food intake.
Published Version
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