Abstract
Two parameters of Ca(2+) dynamics in brain preparations ((45)Ca-uptake to slices and [(3)H]nitrendipine binding to membrane fractions) were measured in naive and chronic morphine-administered rats. While morphine did not have any effect on (45)Ca-uptake to striatal slices in normal Krebs-Ringer solution, it inhibited K(+)-stimulated (45)Ca-uptake to slices. Furthermore, the effect of morphine was antagonized by naloxone. Inhibition of K(+)-stimulated (45)Ca-uptake to striatal slices by morphine was not observed in preparations obtained from chronic morphine-administered rats (6 mg/kg/b.i.d./7 days). In membrane fractions, [(3)H]nitrendipine binding increased by 34% in striatum following chronic morphine treatment, whereas no change was observed in the cortex and hippocampus. The results will be discussed in relation to the phenomena underlying chronic morphine administration.
Published Version
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