Selective Determination of Nicorandil with a Single Planar Solid‐state Potentiometric Ion Selective Electrode

Abstract

AbstractNovel screen‐printed electrodes (SPEs) were constructed for the quantitation of nicorandil (NIC) in its pharmaceutical formulations. Different ion‐exchangers and plasticizers were investigated, but the optimal potentiometric response was obtained using nicorandil‐phosphotungstate (NIC‐PTA) ion associate and tricresyl phosphate as a plasticizer. A Nernstian response of 58.80±1 mV/decade was obtained over a concentration range of (1×10−6–1×10−2) M with 1×10−5 M as a detection limit. Sensor morphology was characterized using scanning electron microscopy (SEM). The method was validated for the assay of NIC with high selectivity, accuracy (average recovery=100.54 %), and precision (%RSD≤2).