Abstract
Two monkeys (Macacamulatta) were trained tomake a go response (go to touch a computer screen) when a red signal (go signal) was presented or a no-go response (inhibit the screen-touching action) when a green signal (no-go signal) was given. The α2-adrenergic antagonist yohimbinewas infused locally, bilaterally and continuously for 8 days into the prefrontal cortex (PFC) by using mini-osmotic pump.The no-go but not go performancewas selectively impaired during the 8 -day administration of yohimbine: the monkeys showed an inability to inhibit the touching response to the no-go signal, indicating that there was a deficit in the inhibitory ability of the animals. Similar infusion of saline into the same cortical area was without effect. The present study provides behavioral pharmacological evidence that α2-adrenoceptors in the PFC are involved in the neural mechanisms underlying response inhibition.
Published Version
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