Abstract
Dopamine-induced postsynaptic responses of both excitory and inhibitory types were recorded from identified neurones of Aplysia ganglion. A 30 sec exposure to 0.1 μm d-lysergic acid diethylamide (LSD) significantly depressed the inhibitory responses to 1 mM dopamine, while a 60 sec exposure to 10 μm LSD did not alter the excitatory responses to 0.1 mm dopamine. Dose-response curves obtained from cells with inhibitory receptors indicate that the mode of LSD interaction was non-competitive.
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