Abstract
The diuretic effect of dopamine (DA) was compared with that of other DA receptor stimulants in rats. While apomorphine (APO) and (±)N-n-propyl-norapomorphine (NPA) failed to increase urine excretion, (3, 4-dihydroxyphenylamino) -2-imidazoline (DPI), a supposed st i mulant of DA inhibitory receptors, exerted a far greater diuretic e f fect than DA itself. The diuretic effect of DA and that of DPI were antagonized by a-adrenergic receptor antagonists such as phentolamine and yohimbine and by bulbocapnine. In contrast, DA receptor blockers such as haloperidol, pimozide, sulpiride and ergometrine were totally ineffective. It is concluded that the diuretic effect of DA and DPI are mediated by stimulation of a-adrenergic receptors.
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