Abstract
Abstract Cationic lipid membranes of N-octadecylchitosan consisting of 2-deoxy-2-octadecylamino-d-glucopyranose, 2-amino-2-deoxy-d-glucopyranose, and 2-acetamido-2-deoxy-d-glucopyranose were covalently immobilized to carboxylated porous supports and used for the adsorption of pyrogenic lipopolysaccharide (LPS). When bovine serum albumin (BSA) solution, including 5 mg mL−1 of BSA and 100—148 ng mL−1 of LPS, was passed through a column packed with the porous supports bearing the cationic lipid membranes, LPS was selectively adsorbed and removed to as low as 0.1 ng mL−1 with quantitative recovery of BSA. LPS seemed to be dissociated from molecular complexes with BSA, and adsorbed selectively to the cationic lipid membranes by both an ionic interaction and a hydrophobic one.
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