Selection of Human Cytomegalovirus Screening Target Population in Voluntary Blood Donors in Beijing City of China

Abstract

To find a group of the highest proportion of HCMV antibody negative among the voluntary blood donors in Beijing, and to establish a database for the special clinical blood needs. The blood samples were collected from 2518 eligible donors who were randomly selected according to the national compulsory blood screening programs, the HCMV-IgG antibody were detected by using enzyme linked immunosorbent assay (ELISA). According to blood donors of different sex, age, educational degree, born area, the results of detection were analyzed and compared. The HCMV-IgG antibody negative rate of eligible blood donors in Beijing was 10.68% (269/2518). According to the different sex, the HCMV-IgG antibody negative rate was 11.84% (210/1774) for men, and was 7.93% (59/744) for women. In comparsion with different ages, the HCMV-IgG antibody negative rate of 18-25 years old men was 13.51% (181/1340), the HCMV-IgG antibody negative rate of 26-30 year old men was 8.68% (62/714), the HCMV-IgG antibody negative rate of 31-35 year old men was 5.60% (26/464). Along with the age growth, the HCMV-IgG antibody negative rate gradually decreased. In comparison with different born area, the HCMV-IgG antibody negative rate was the highest in area of Beijing and Tianjin (18.59%, 50/269). In comparison with different educational levels, the HCMV-IgG antibody negative rate was the highest in men who have achieved bachelor or above (13.52%, 86/636). The HCMV antibody screening in the Beijing voluntary blood donors needs to select the 18-25 year old male population whose educational level have achieved bachelor or above. The organization or establishment of this group can provide a base for HCMV antibody screening strategy.