Selection Criteria of Cord Blood Units for Platelet Gel Production: Proposed Directions from Hellenic Cord Blood Bank. Comment on Mallis et al. Short Term Results of Fibrin Gel Obtained from Cord Blood Units: A Preliminary in Vitro Study. Bioengineering 2019, 6, 66.

Panagiotis Mallis,Vasiliki Gkioka,Catherine Stavropoulos-Giokas,Zetta Dimou,Eleni Georgiou,Eirini Faidra Sarri,Efstathios Michalopoulos,Effrosyni Panagouli

doi:10.3390/bioengineering8050053

Abstract

This article provides additional knowledge for cord blood platelet gel (CBPG) production. Recently, it has been shown that CBPG exerts beneficial properties in wound healing applications. CBPG is produced after a two-step centrifugation process, following the addition of calcium gluconate. Clinical-grade CBPG can be produced in public cord blood banks, worldwide. However, standardization of the CBPG production process must be established in order to reduce discrepancies that occurred due to different platelet gel preparations. This article aims to provide an update regarding the selection criteria of cord blood units (CBUs), and to provide evidence for the improvement of the CBPG production process. (Comment on “Short Term Results of Fibrin Gel Obtained from Cord Blood Units: A Preliminary in Vitro Study” Bioengineering 2019, 6, 66).

Highlights

Panagiotis Mallis *, Efstathios Michalopoulos, Effrosyni Panagouli, Zetta Dimou, Eirini Faidra Sarri, Eleni Georgiou, Vasiliki Gkioka and Catherine Stavropoulos-Giokas
Rebulla et al [13] proposed the production of cord blood platelet gel (CBPG) from Cord Blood Units (CBUs) that do not meet the criteria for hemopoietic stem cell (HSC) isolation, banking, and release for transplantation, as defined by the Foundation for the Accreditation of Cellular Therapy—NetCord (FACT-NetCord) standards [14]
Based on previous results from our lab [16], we have shown the efficient production of CBPG, utilizing low volume cord blood units (CBUs)

Summary

Introduction

Panagiotis Mallis * , Efstathios Michalopoulos , Effrosyni Panagouli, Zetta Dimou, Eirini Faidra Sarri, Eleni Georgiou, Vasiliki Gkioka and Catherine Stavropoulos-Giokas. Dear Editor, The content of this article concerns the optimization and standardization of the platelet gel (PG) manual production process which utilizes cord blood (CB). Rebulla et al [13] proposed the production of CBPG from Cord Blood Units (CBUs) that do not meet the criteria for hemopoietic stem cell (HSC) isolation, banking, and release for transplantation, as defined by the Foundation for the Accreditation of Cellular Therapy—NetCord (FACT-NetCord) standards [14].

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