Abstract
Somatodendritic transmitter release refers to the release of a neuroactive substance from the cell body (soma) and dendrites of a neuron. Initial reports of somatodendritic release were pioneering (1,2) and the results unexpected given that transmitter release is a well-recognized function of axons. Indeed, the conventional textbook image of a neuron shows a cell body and dendrites that receive synaptic input on one end and a long axon with a vesicle-containing terminals and diffusing clouds of released transmitter on the other end (Figure 1A).
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