Sedative effect of propofol and midazolam in surgery under spinal anaesthesia: A comparative study

Abstract

Intravenous medications are invariably required to allay anxiety related to surgical procedures, in patients undergoing surgery under regional anesthesia. A thorough pre anaesthetic check up and details of the surgical procedure planned are necessary before administration of sedative agents to attain desirable levels of sedation and avoid unwanted adverse events. To observe, record and analyse sedative effect of intravenous Propofol and Midazolam in lower extremities and lower abdominal surgery scheduled under regional anesthesia techniques.: A single blinded comparative study conducted in tertiary care hospital of Gujarat. Sixty patients with no organic pathology & a moderate but definite systemic disturbance categorized into two groups labeled as propofol group (n=30) and Midazolam group (n=30) of either gender and shortlisted for surgery using subarachnoid block. Observer’s Assessment of Alertness/Sedation Scale (OAA/S Scale) and Ramsay sedation scale was used to assess effective sedation.: Basic patients characteristics, Mean age (SD) was 31.57 + 10.57 years in category I (P group) and 35.33 + 9.98 years in category II (M group) was comparable between the groups. In category I 16(53.3%) patients reached targeted sedation level in < 60 seconds, in group M 18 (60%) patients required 90-120 seconds to achieved the same level of sedation (p<0.001). Propofol gives rapid onset of sedation and faster recovery, while midazolam provides more hemodynamic stability in regional anesthesia.