Abstract
ABSTRACT. Plasma levels and adrenal secretion rates of deoxycorticosterone (DOC) were measured in pregnant and nonpregnant dogs by a double-isotope derivative assay.The removal rates of DOC and aldosterone were also determined following the intravenous injection of these tritiated hormones in pregnant and nonpregnant dogs. Plasma DOC concentrations averaged 2.7 (±1.3 SEM) ng⁄ml for 4 conscious pregnant dogs compared to 4.3 (±0.7) ng⁄ml for 6 nonpregnant dogs. The secretion rate of DOC in 3 anesthetized pregnant dogs averaged 377 (±51) ng⁄min compared to 503 ± 78 ng⁄min for 7 nonpregnant dogs. The differences in plasma DOC concentration and DOC secretion rate in the pregnant and nonpregnant groups were not statistically significant (NS = p > 0.05). In 4 pregnant dogs the plasma half-life ° (t½) for DOC was 24.9 min while the t½ for DOC in 5 nonpregnant dogs averaged 20.7 min (NS); the t½ for aldosterone in 5 pregnant dogs averaged 21.1 min while in 6 nonpregnant dogs the aldosterone t½ averaged 20.3 min (N...
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