Abstract
Objective To investigate the secondary metabolites of the South China Sea sponge Acanthella cavernosa.Methods The acetone extract of A.cavernosa was purified by repeated column chromatography on silica gel,sephadex LH-20,and high-performance liquid chromatography(HPLC).Structures of the extract were determined by spectroscopic analysis and comparison with previously reported data.Results and Conclusion A total of 7compounds were isolated and their structures were identified as kalihinene X-Z(1-3),(R)-3,5-diethyl-5-((S,E)-2-ethylhex-3-en-1-yl)furan-2(5H)-one(4),methyl(2Z,6R,8S)-4,6-diethyl-3,6-epoxy-8-methyldodeca-2,4-dienoate(5),methyl(2Z,6R,8R,9E)-3,6-epoxy-4,6,8-triethyl-2,4,9-dodecatrienoate(6),and methyl(2Z,6R,8S)-3,6-epoxy-4,6,8-triethyldodeca-2,4-dienoate(7);and compounds 4-7 were identified from the genus Acanthallafor the first time.
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