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Abstract
Two new 13-hydroxycembrane diterpenoids, arbolides A (1) and B (2), along with a known trihydroxysteroid, crassarosterol A (3), were isolated from the soft coral Sinularia arborea. The structures of new cembranes 1 and 2 were elucidated by spectroscopic methods. Steroid 3 was found to exhibit cytotoxicity toward K562 and MOLT-4 leukemia.
Highlights
Previous studies on the chemical constituents of soft corals belonging to the genus Sinularia have led to the isolation of a number of interesting secondary metabolites and some of these were found to possess extensive bioactivities [1,2,3]
Correlations (Table 2 and Figure 4) further established the planar structure of 2 as a cembrane-type diterpenoid bearing a hydroxy group at C-13, two trisubstituted carbon-carbon double bonds at C-7/8 and C-11/12, a 1,1-disubstituted carbon-carbon double bond at C-15/17 and a methyl-containing epoxide at C-3/4
The normal phase HPLC (NP-HPLC) was performed using a system comprised of a Hitachi L-7110 pump
Summary
Previous studies on the chemical constituents of soft corals belonging to the genus Sinularia have led to the isolation of a number of interesting secondary metabolites and some of these were found to possess extensive bioactivities [1,2,3]. Continuation investigation on the chemical constituents of the marine invertebrates collected off the waters of Taiwan, two new cembrane-type diterpenoids, arbolides A (1) and B (2), and a known steroid, crassarosterol A (3) [4], were isolated from the soft coral Sinularia arborea (family Alcyonacea) (Figure 1). We describe the isolation, structure determination and cytotoxicity of compounds 1–3
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