Abstract
The soil-derived fungus Aspergillus sp. isolated from the rhizospheric soil of Phoenix dactylifera (Date palm tree) and cultured on the large scale solid rice medium yielded a novel compound 1-(4-hydroxy-2,6-dimethoxy-3,5-dimethylphenyl)-2-methyl-1-butanone (1) and four known compounds; citricin (2), dihydrocitrinone (3), 2, 3, 4-trimethyl-5, 7-dihydroxy-2, 3-dihydrobenzofuran (4) and oricinol (5). The structures of the isolated compounds were elucidated by MS, 1H, 13C and 2D NMR spectra. Compound (1) exhibited potent antimicrobial activities against Staphylococcus aureus with MIC values of 2.3 μg mL−1 and significant growth inhibitions of 82.3 ± 3.3 against Candida albicans and of 79.2 ± 2.6 against Candida parapsilosis. This is the first report to isolate metabolites from the fungus Aspergillus found in temperate region date plant rhizospheres.
Highlights
The rhizosphere is the portion of the soil which is surrounding the plant root [1, 2]
A plethora of work has been done on the fungal culture of the obtained microorganism from these soils which led to the isolation of novel biologically active constituents
In our ongoing research on the findings of soil based microorganism and its culture for the identification of secondary metabolites, we worked on the crude ethyl acetate extract of the interrhizospheric fungus (Aspergillus sp.)
Summary
The rhizosphere is the portion of the soil which is surrounding the plant root [1, 2]. As a part of our ongoing search on bioactive fungal secondary metabolites from unexplored niches [23, 24], Orfali and Perveen BMC Chemistry (2019) 13:103 in this study, a fungal strain RO-17-3-2-4-1, identified as Aspergillus sp., was isolated from the rhizosphere soil of P. dactylifera, Wadi Hanifa, 15 km Northwest of Riyadh, Saudi Arabia. To the best of our knowledge, it is the first research report on the isolation of secondary metabolites from the rizosphere soil of temperate region plants P. dactylifera.
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