Abstract
Serratia marcescens produces secondary metabolites, which are bioactive chemicals generated during its non-essential metabolic activities. These secondary metabolites are renowned for their antibacterial, antifungal, and anticancer capabilities. This work analyzed the chemical composition and antibacterial properties of the secondary metabolite of Serratia marcescens isolated from the local environment. Serratia marcescens was isolated using standard microbiological techniques and identified based on morphological and biochemical characteristics. Gas chromatographymass spectrometric analysis revealed the presence of eighteen (18) bioactive compounds, comprising oleic acid as the most abundant compound (21.9013 %), 9,12-Octadecadien-1-ol, (Z, Z)- (11.9854 %), and other compounds with less than 6 % abundance. The metabolite has antibacterial activities against Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris, and Bacillus subtilis. Antibacterial activity was higher against Bacillus subtilis (42.00±2.65 mm) and Proteus vulgaris (32.67±1.15 mm), and least with Pseudomonas aeruginosa (10.00±2.00 mm) at 400 mg metabolite concentration. The antibacterial effect decreased with a decrease in the concentration of the metabolite. The results show that Serratia marcescens exhibits potential as an antibacterial agent within the pharmaceutical and food sectors.
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