Abstract
Benign secondary hyperparathyroidism was induced in rats by experimental chronic renal disease. A gross parathyroid gland enlargement was present in 6 out of 11 rats. The cells of the enlarged parathyroid glands had increased tortuosity of the cytoplasmic membranes, enlarged mitochondria with increased electron lucency of their mitochondrial matrix, and an apparently increased number of ribosomes. The Golgi apparatuses were prominent and had numerous Golgi vesicles. It is suggested that the formation of secretory material of parathyroid glands takes place at rough endoplasmic reticula. A similarity of morphologic changes of the enlarged parathyroid glands of the 5 6 nephrectomized rats to those seen by others in stimulated glands in vivo and in vitro appears to indicate that the mechanism of control of parathyroid hormone synthesis and secretion is similar in both in vivo and in vitro systems and is not interfered with by uremia.
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