Abstract
Publisher Summary This chapter is concerned with secondary deuterium kinetic isotope effects. The chapter illustrates some of the important recent advances in the interpretation and uses of these kinetic isotope effects to elucidate reaction mechanisms. Other excellent reviews of secondary deuterium kinetic isotope effects (KIEs) have also been discussed in the chapter. The chapter demonstrates the ways in which secondary deuterium and tritium KIEs can be used to elucidate the mechanisms of reactions and determine the structure of their transition states. Secondary a-deuterium KIEs have been widely used to determine the mechanism of S N reactions and to elucidate the structure of their transition states. Some of the significant studies illustrating these principles are presented in this chapter. In particular, the advantages of using both theoretical calculations and experimental data to solve these problems have been emphasized in the chapter.
Published Version
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