Abstract
Antimicrobial coatings covalently grafted on the implant surfaces are considered to be one of the powerful weapons to prevent implant-associated infections. β-Peptide polymers and host defense peptide mimicking polymers are considered promising candidates to fight against drug-resistant bacteria. Here, we compared the antimicrobial activity of Au surface modified by these β-peptide polymers containing primary, secondary, and tertiary amino groups in the side chains. Copolymer P3 containing secondary amino groups was found to have high antibacterial activity. P3-modified thermoplastic polyurethane (TPU) can serve as a promising antimicrobial material for practical application, because of its effective prevention of TPU-related infection and the promotion of host cell growth in the subcutaneous implant infection model.
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