Abstract
In France, the only second-generation tyrosine-kinase inhibitor (2GTKIs) available as a first-line treatment is nilotinib. Trials comparing nilotinib with imatinib and dasatinib with imatinib favour 2GTKIs, which have faster, deeper and earlier molecular responses. However, a reduction in progress is also observed only in a small number of patients. Moreover, survival rates after 3 years are comparable for imatinib and 2GTKIs. For the initial imatinib prescription, it is important to take into consideration the early molecular response (between 3 to 6 months) so treatment modifications for patients considered as non-responders can be made as soon as possible. For prescriptions of 2GTKIs, it is important to take into consideration the comorbidities of patients and to implement a monitoring programme to detect and prevent emerging side effects.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
