Abstract
SummaryPlacental biopsy was carried out in a total of 283 pregnant women between 1989 and 1994, the main indication being abnormal ultrasound signs (68.6 per cent) detected in the second and third trimesters. Successful sampling was achieved in 98.6 per cent of the cases. Excluding the first year, karyotypic results were obtained in 98.2 per cent of received samples. Out of these, 6.5 per cent were abnormal, and confirmed by the culture method, amniocentesis, or cordocentesis. In addition, one case of mosaic trisomy 8 was confirmed to be confined to the placenta (0.4 per cent). A spontaneous abortion rate of 2.1 per cent was observed, but not necessarily procedure-related. We had one false-negative report. In conclusion, we found placental sampling to be a useful method allowing a rapid decision to be taken regarding further management of at risk pregnancies.
Published Version
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