Seaweed-mediated biosynthesis of silver nanoparticles using Gracilaria corticata for its antifungal activity against Candida spp.

P Kumar,S Senthamil Selvi,M Govindaraju

doi:10.1007/s13204-012-0151-3

P Kumar, S Senthamil Selvi + Show 1 more

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https://doi.org/10.1007/s13204-012-0151-3

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Journal: Applied nanoscience	Publication Date: Aug 7, 2012
Citations: 130	License type: cc-by

Affiliation: Bharathidasan University

Abstract

The present study was demonstrated with simple and rapid synthesis of silver (Ag) nanoparticles using marine seaweed, Gracilaria corticata. The visibility of prominent color change at 60 °C within 20 min indicates the formation of Ag nanoparticles. The synthesized Ag nanoparticles were well characterized by UV–vis spectrum, Fourier infrared spectroscopy (FTIR), transmission electron microscopy (TEM) and dynamic light scattering measurements (DLS). Prominent FTIR peaks were obtained corresponding to phenolic compounds, amide I group and aromatic rings which involved in the stabilization of Ag nanoparticles. G. corticata resulted in spherical shaped nanospheres of 18–46 nm as revealed by TEM. The average size distributions of Ag nanoparticles were 51.82 nm and are fairly stable with a zeta potential value of −26.2 mV. The result showed that, biosynthesized Ag nanoparticles from G. corticata have an effective antifungal activity against Candida albicans and C. glabrata.

Highlights

Candida spp. are ubiquitous fungi and are most arguable opportunistic pathogen of immunocompromised hosts.S
Appl Nanosci (2013) 3:495–500 above information in mind, we report on the seaweedmediated reduction of silver into Ag nanoparticles using Gracilaria corticata for its antifungal activity against Candida spp
The color of solution gradually intensified on heating, which indicates the synthesis of Ag nanoparticles

Summary

Introduction

Candida spp. are ubiquitous fungi and are most arguable opportunistic pathogen of immunocompromised hosts.S. Candida spp. are ubiquitous fungi and are most arguable opportunistic pathogen of immunocompromised hosts. Treating infection caused by Candida spp. have become a hectic problem due to serious side effects like renal and liver dysfunction associated with the polyenes (i.e., amphotericin B, nystatin) (Hoeharner et al 2010). A significant increase in resistance to the less toxic azole drugs (i.e., fluconoazole) has occurred (White et al 2002). Considering all these possibilities, there remains a pressing need for progress in the development of reliable diagnostic technology with improved antifungal activity

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