Abstract
The following studies were undertaken to compare seasonal effects of insulin on [U 14C] glucose oxidation by adipocytes of the edible dormouse ( Glis glis). The rate of insulin-induced glucose oxidation changed according to the season. The highest oxidation rate was in autumn, followed by a significant decrease during winter which became more marked in spring and was stabilized at the lowest level in summer. The affinity of fat cells for insulin (expressed in terms of the insulin concentration necessary to obtain half the maximum response) remained the same in all seasons. These results suggest that modifications of insulin action during the annual cycle result from seasonal variations in glucose metabolic pathways in the adipocytes.
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