Abstract
Miconia chamissois Naudin is a species from the Cerrado, which is being increasingly researched for its therapeutic potential. The aim of this study was to obtain a standardized extract and to evaluate seasonal chemical variations. Seven batches of aqueous extracts from leaves were produced for the standardization. These extracts were evaluated for total solids, polyphenol (TPC) and flavonoid content (TFC), vitexin derivative content, antioxidant activity; thin-layer chromatography (TLC), and high-performance liquid chromatography (HPLC) profiles were generated. For the seasonal study, leaves were collected from five different periods (May 2017 to August 2018). The results were correlated with meteorological data (global radiation, temperature, and rainfall index). Using chromatographic and spectroscopic techniques, apigenin C-glycosides (vitexin/isovitexin) and derivatives, luteolin C-glycosides (orientin/isoorientin) and derivatives, a quercetin glycoside, miconioside B, matteucinol-7-O-β-apiofuranosyl (1 → 6) -β-glucopyranoside, and farrerol were identified. Quality parameters, including chemical marker quantification by HPLC, and biological activity, are described. In the extract standardization process, all the evaluated parameters showed low variability. The seasonality study revealed no significant correlations (p < 0.05) between TPC or TFC content and meteorological data. These results showed that it is possible to obtain extracts from M. chamissois at any time of the year without significant differences in composition.
Highlights
Cerrado, with a predominantly dry and hot climate, is recognized as the richest savanna in the world, home to 11,627 species of native plants already cataloged [1]
Miconia chamissois Naudin is a native species from Brazil found in the Caatinga, Cerrado, and Atlantic Forest [4]
Miconia chamissois Naudin leaves were collected from Lago do Cedro, Brasília, Federal District, Brazil
Summary
With a predominantly dry and hot climate, is recognized as the richest savanna in the world, home to 11,627 species of native plants already cataloged [1]. Melastomataceae is the sixth most abundant botanical family of angiosperms in Brazil, comprising more than 1300 species, with Miconia, Leandra, Tibouchina, Microlicia, and Clidemia among the most diverse genera. In all of Brazil, 267 species from the Miconia genus have been described and are distributed in these phytogeographic domains: Amazon, Caatinga, Cerrado, Atlantic Forest, Pampa, and Pantanal [4]. In the Cerrado, which principally covers the Midwest region of Brazil, 68 Miconia species have already been identified [2]. Miconia chamissois Naudin is a native species from Brazil found in the Caatinga, Cerrado, and Atlantic Forest [4]
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