Abstract
Background: Pathophysiological mechanisms of IrritableBowel Syndrome (IBS) are unknown and there are no specific markers unique to this disorder. The hypothesis of a subclinical gradual development of local intestinal inflammation which generates IBS remains to be confirmed. The aim of the study was to search for a laboratory parameter or their panel among the acute-phase proteins in the blood and con firm their possible association with faecal calprotectin and alpha-1-antitrypsin which are spec ific markers for local intestinal inflammation.
Highlights
Irritable bowel syndrome (IBS) is regarded as a functional bowel disorder, which means that no identifiable pathophysiological mechanism unique to Irritable Bowel Syndrome (IBS) has been established [1,2]
Because of the differences in the water content of faeces between the three forms of IBS, diarrhoea-predominant, constipation-predominant and alternating diarrhoea and constipation, faecal calprotectin concentrations are expressed in μg/g fresh faeces and μg/g dry faeces
Markers determined in faeces are organ-specific and as such may prove superior in the diagnosis of intestinal inflammation
Summary
Irritable bowel syndrome (IBS) is regarded as a functional bowel disorder, which means that no identifiable pathophysiological mechanism unique to IBS has been established [1,2]. Quantitative measurements of biomarkers in blood serum and stool are reproducible and allow the diagnosis of the specific pathological process and the estimation of its activity, evolution and prognosis, including the prediction of the response to treatment In clinical practice, they have the advantage of being a non-invasive diagnostic tool unlike endoscopy, provide additional clinical data, are not costly, and are easy to perform [8, 9,10,11,12]. Significant correlation between faecal calprotectin and serum ORS in diarrhoea-predominant IBS suggest the usefulness of the two parameters as a diagnostic panel to screen patients with suspicion of IBS for low-grade intestinal inflammation
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