Sea buckthorn fruits – Potential lipid-lowering activity and preventive role in atherosclerosis-linked low-grade inflammation from epithelial cells to leukocytes response

Abstract

Background and Aims : The extracts from fruits of sea buckthorn (Hippophaë rhamnoides, HR) have been considered in the protection against hipoxia-induced transvascular fluid leakage in rats [1] and oxidized low-density lipoprotein induced injuries of endothelial cells [2]. The first aim of the study was an assessment of anti-inflammatory activity of an aqueous extract of HR fruit (5-100 μg/mL) expressed as inhibition of cytokines (IL-8, IL-6, IL-10, TNF-α, IL-1β) secretion in LPS/IL1β-stimulated human neutrophils, monocytes/macrophages, and differentiated human adenocarcinoma Caco-2 cell line.