Abstract
Elevation of urinary uroporphyrin occurs regularly in the porphyrias and is a relatively specific phenomenon. Urinary uroporphyrin must be purified and concentrated for qualitative demonstration at low but clinically significant levels. A new procedure based on the adsorption of uroporphyrin to talc, its insolubility in ether, and its brilliant red fluorescence under ultraviolet light is a rapid and highly sensitive screening test. Unlike other methods now in use, this test is significant when negative. Urine specimens from 12 patients with porphyria and 74 of 75 random hospital specimens of urine containing 50 to 100 mcg. per liter of added uroporphyrin gave positive tests while weak positive reactions were seen in only 6 of the same 75 specimens without added uroporphyrin.
Published Version
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