Abstract
Objectives:Ethanol extract of the stem of Bauhinia purpurea Linn. was subjected to analgesic and anti-inflammatory activities in animal models.Materials and Methods:Albino Wistar rats and mice were the experimental animals respectively. Different CNS depressant paradigms like analgesic activity (determined by Eddy's hot plate method and acetic acid writhing method) and anti-inflammatory activity determined by carrageenan induced paw edema using plethysmometer in albino rats) were carried out, following the intra-peritoneal administration of ethanol extract of Bauhinia purpurea Linn. (BP) at the dose level of 50 mg/kg and 100 mg/kg.Results:The analgesic and anti-inflammatory activities of ethanol extracts of BP were significant (P < 0.001). The maximum analgesic effect was observed at 120 min at the dose of 100 mg/kg (i.p.) and was comparable to that of standard analgin (150 mg/kg) and the percentage of edema inhibition effect was 46.4% and 77% for 50 mg/kg and 100 mg/kg (i.p) respectively. Anti-inflammatory activity was compared with standard Diclofenac sodium (5 mg/kg).Conclusion:Ethanol extract of Bauhinia purpurea has shown significant analgesic and anti-inflammatory activities at the dose of 100 mg/kg and was comparable with corresponding standard drugs. The activity was attributed to the presence of phytoconstituents in the tested extract.
Highlights
Bauhinia purpurea (Leguminosae) is a medium sized deciduous tree, sparingly grown in India
Its decoctions are recommended for ulcers as a useful wash solution.[2]
Analgesic activity Ethanol extract of Bauhinia purpurea Linn. (BP) exhibited maximum analgesic activity at 120 min. at 100 mg (i.p.), (P < 0.01) and it was significant when compared with control group, but slightly
Summary
Bauhinia purpurea (Leguminosae) is a medium sized deciduous tree, sparingly grown in India. This plant is used traditionally in dropsy, pain, rheumatism, convulsions, delirium, and septicemia.[1] The bark of the plant is used as an astringent in the treatment of diarrhea. Its decoctions are recommended for ulcers as a useful wash solution.[2] The aerial parts of the plant are reported to contain flavone gylcosides, foliar flavonoids, 6-butyl-3-hydroxy flavanone, amino acids, phenyl fatty ester, lutine and β-sitosterol.[3,4,5,6,7,8] These active constituents have been attributed the therapeutic activity of the plant. The present study was undertaken to evaluate their analgesic and anti-inflammatory activities
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
