Abstract
Ethanol extract of the leaves of Justicia gendarussa Burm was subjected to analgesic and anti-inflammatory activities in animal models. Albino Wistar rats and mice were the experimental animals respectively. Different CNS depressant paradigms like analgesic (determined via Eddy's hot plate approach and acetic acid writhing approach) and antiinflammatory activity (determined via carrageenan induced paw edema using plethysmometer in albino rats) were carried out, following the intra-peritoneal administration of ethanol extract of formulation Justicia gendarussa Burm leaves (EEJG) at the dose level of 250mg/kg and 500mg/kg. The analgesic and anti-inflammatory activities of ethanol extracts of EEJG showed significant results (P andlt. The maximum analgesic activity was observed at 120 min at the dose of 500mg/kg (i.p.) and analgesic and anti-inflammatory activity was compared with standard drug Diclofenac sodium (5 mg/kg). Ethanol extract of Justicia gendarussa Burm leaves has shown significant analgesic and anti-inflammatory activities at the dose of 500mg/kg and was comparable with corresponding standard drugs. The activity was attributed to the presence of phytoconstituents in the tested extract.
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