Abstract
Objective: The objective of the study was to study the pet ether, ethyl acetate, and ethanol leaf extracts of Canthium dicoccum and Amischophacelus axillaris for anthelmintic activity and antihypertensive activity.
 Methods: The antihypertensive activity was carried out by employing a colorimetric assay based on the hydrolysis of Histidyl-Hippuryl-Leucine and anthelmintic activity carried out against Indian earthworm Pheritimaposthuma.
 Results: The pet ether leaf extract both the plants exhibited the maximum antihypertensive activity with a percent inhibition of 64.82 for C. dicoccum (Gaertn.) and 84.12 for A. axillaris (L.) as compared with Captopril showing percent inhibition 85.37 and for anthelmintic activity, it is found that ethanol extract of C. dicoccum and ethyl acetate extract of A. axillaris exhibited significant activity against the standard drug albendazole.
 Conclusion: This study investigated the potential of C. dicoccum and A. axillaris as a new source against the antihypertensive activity. The outcome of anthelmintic activity revealed that the ethyl acetate and ethanol extracts exhibited a considerable amount of anthelmintic activity, which is mainly due to the active phytoconstituents present in the extracts.
Highlights
Hypertension is nowadays common among people of all age groups
The preliminary evaluation of the crude extracts of C. dicoccum and A. axillaris showed that both the plants are a potential source of bioactive compounds that can inhibit the activity of angiotensin-converting enzyme (ACE)
The present study suggests that the leaves of C. dicoccum and A. axillaris possess ACE inhibitory that might be helpful in treating hypertension
Summary
Hypertension is nowadays common among people of all age groups. It does not give any early warning symptoms, but it exerts more load on heart and blood vessels due to which it is termed as a silent killer. Immense importance has been given to the study of hypertension with the development of a realistic method to measure it in the past century due to constant change in the lifestyle of people. Few case studies have yielded significant results proving the treatments are effective in lowering blood pressure and improving outcomes with minor setbacks. Helminthiasis is one of the common agents of infection rampantly prevailing in developing as well as underdeveloped countries. Medicinal plants which are rich in botanical anthelmintics [7,3] serve as an alternate source for the development of more effective and less toxic medicines which has encouraged further research and development in analyzing new plant-derived medicines
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