Screening of Phellinus linteus, a Medicinal Mushroom, for Anti-viral Activity

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Harmful viruses, including dengue virus, human immunodeficiency virus, and hepatitis B virus are known to be extremely sensitive to glucosidase inhibition. Phellinus linteus, an edible medicinal mushroom, was screened as an α-glucosidase inhibitor. The methanol extract of P. Linteus inhibited the trafficking process of Newcastle disease virus-hemagglutinin-neuramidase, a viral glycoprotein, in virus-infected baby hamster kidney cells. These results suggest that P. Linteus extract inhibits viral glycoprotein expression on cell surface through inhibition of trafficking process rather than glycoprotein synthesis.