Abstract
Introduction: As the amyloid precursor protein performs a remarkable part in chronic periodontitis and the progression of Alzheimer's disease growth, discoveryof novelactive inhibitors of this protein can be of great standing in the treatment of periodontitis. Chronic periodontitis is one of the causative factors and metabolic stressor for diabetes control. In chronic periodontitis and Alzheimer's disease, some molecules have been proposed to inhibit proteins in past.
 Methods: This study was planned to find present potent inhibitors,A library of KDM compounds was obtained from Chem Div Database. Here, all complexes with goodglide score were short listed for analysis of protein-ligand interaction. Calculations were carried out to estimate the interaction of the ligands selected in complex with the beta amyloid protein.
 Results: Five top hits were found considering Curcuminas reference. Five small molecules have been proposed as possible inhibitors of this protein. Here in this study, we have focused on small molecule lead inhibitors for identification of Chronic Periodontitis and Alzheimer's disease.
Highlights
As the amyloid precursor protein performs a remarkable part in chronic periodontitis and the progression of Alzheimer's disease growth, discoveryof novelactive inhibitors of this protein can be of great standing in the treatment of periodontitis
Microbiological, and inflammatory reports support this connotation, demonstrating that periodontal pathogens may contribute to neural soreness and AD.This study is based on the established relationship between periodontal diseases and AD [1,2,3,4,5,6,7]
De novo drug discovery has faced serious problems due to its cost and time consuming.Several studies have proven a significant link between amyloid load and periodontal diseases [4]
Summary
As the amyloid precursor protein performs a remarkable part in chronic periodontitis and the progression of Alzheimer's disease growth, discoveryof novelactive inhibitors of this protein can be of great standing in the treatment of periodontitis. In chronic periodontitis and Alzheimer's disease, some molecules have been proposed to inhibit proteins in past. Calculations were carried out to estimate the interaction of the ligands selected in complex with the beta amyloid protein. Five small molecules have been proposed as possible inhibitors of this protein. We have focused on small molecule lead inhibitors for identification of Chronic Periodontitis and Alzheimer's disease. The involvement of periodontitis as a factor for a number of chronic diseases is widely proposed and there is rising different hypothesis-based indication for a relationof periodontitis with AD. A number ofof lifestyle factors including nutritional habits are thought to affect gene expression
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