Abstract
Andrographis paniculata is an important medicinal plant which has been used to treat various ailments. The present study was undertaken to analyze the phytochemical compounds and evaluated the antioxidant and genotoxic potential of Andrographis paniculata leaves and whole plant extracts. Phytochemical compounds analyzed by qualitative and quantitative analysis of methanol extracts of the leaves and whole plant extracts which showed the presence of Alkaloids, Carbohydrate, Resins, Saponins, Flavonoid, Steroids, Glycosides and Tannin. Quantitative analysis were also conducted to determine the amount of Alkaloids, Flavonoids, Saponins and Tannin by HPTLC Finger printing methods in A. paniculata ( A.P.) leaves and whole plant .The Antioxidant activity of A. paniculata Methanolic extract was evaluated by Fenton methods which showed the dose dependent Inhibition of TBARS formation. The Genotoxicity was evaluated by Micronucleus Assay. The dose dependent prevention of bone marrow micronucleus formation by Andrographis paniculata leaves and whole plant extracts was observed. Therefore, Andrographis paniculata leaves and whole plant extract caused antioxidant and genotoxic potential.
Highlights
Plants have been an important source of medicine to living organism for thousands of years
Quantitative analysis were conducted to determine the amount of Alkaloids, Flavonoids, Saponins and Tannin by HPTLC Finger printing methods in A. paniculata ( A.P.) leaves and whole plant .The Antioxidant activity of A. paniculata Methanolic extract was evaluated by Fenton methods which showed the dose dependent Inhibition of Thiobarbeturic Acid Reaction Substances (TBARS) formation
The preliminary phytochemical screening tests may be helpful in the identification of the bioactive principles and may lead to drug discovery and development
Summary
Plants have been an important source of medicine to living organism for thousands of years. Plants are contemplated as dietary supplement to living organism and traditionally used for treatment of many health problems 1. Andrographis paniculata is called as Kalmegh or “King of Bitters.”. This plant is an extremely bitter in taste that is used to treat liver disorders, bowel complaints of children, colic pain, common cold and upper respiratory tract infection 2,3,4. It is used for the treatment of snake bite, bug bite, diabetes, dysentery, fever, and malaria 5. AP has been reported to have a broad range of pharmacological
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