Abstract
Diabetic retinopathy (DR) is a leading cause of blindness among working-age adults. Therefore, it is important to detect DR accurately during mass screening. The purpose of this study was to determine whether a small, hand-held, mydriasis-free, full-field flicker electroretinographic (ERGs) device called RETeval can be used to screen for DR. To accomplish this, we recorded full-field flicker ERGs with this device from 48 normal eyes and 118 eyes with different severities of DR in patients with diabetes mellitus (DM). This system delivered a constant flash retinal luminance by adjusting the flash luminance that compensated for changes in the pupil size. Our results showed that there were significant correlations between the severity of DR and the implicit times (P < 0.001; r = 0.55) and the amplitudes (P = 0.001; r = −0.29). When the implicit time was used for the index, the area under the receiver operating characteristic curve was 0.84 for the detection of DR, and was 0.89 for the detection of DR requiring ophthalmic treatments. These results suggest that the implicit times of the flicker ERGs recorded by the small, mydryasis-free ERG system can be used as an adjunctive tool to screen for DR.
Highlights
The RETeval device can identify the patients with diabetes mellitus (DM) as not having vision-threatening diabetic retinopathy with 99% accuracy
The results demonstrated that the implicit time of the flicker ERGs recorded and analyzed by the RETeval system was more highly correlated with the severity of the Diabetic retinopathy (DR) than the amplitude (Fig. 3)
The implicit times had higher area under the curve (AUC) of the receiver operating characteristic (ROC) curve for the detection of both DR and DR requiring ophthalmological therapy (Fig. 4). These findings suggest that the implicit time of the flicker ERG recorded by RETeval can be used for the screening of DR
Summary
The RETeval device can identify the patients with diabetes mellitus (DM) as not having vision-threatening diabetic retinopathy with 99% accuracy. As best we know, it has not been determined whether the RETeval device can be used to identify patients with DR. The purpose of this study was to determine whether the RETeval system can be used for the mass-screening of eyes that have DR.
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