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Abstract
The pharmaceutical cocrystals are nowdays intensively studied due to the improvements of solubility, stability, processability, etc. of the drugs. In this work, the cocrystals of betulin with terephthalic acid as a coformer were prepared by liquid-assisted grinding method. The formation of cocrystals was confirmed by powder X-ray diffraction, IR spectroscopy and thermal analysis methods. HPLC analysis showed that in the case of betulin – terephthalic acid cocrystals, solubility of betulin was significantly improved compared to the initial betulin as well as betulin from cocrystals with aliphatic dicarboxylic acids which were earlier prepared.
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