Sclerosing Therapy for Small Intraoral Hemangiomas with Monoethanolamine Oleate: Four Successful Cases

Abstract

Monoethanolamine oleate (Ethamolin) is commonly used in medicine in sclerosing therapy for small varicose veins. The drug acts by irritating the intimal endothelium of the vein leading to a dose-dependent sterile inflammatory response, which results in fibrosis of vessel walls. Hemangiomas are benign vascular lesions that may appear at birth, in childhood, or in adult life, sometimes occurring in the oral cavity. Endothelial cell proliferation and angiogenesis are the histopathological features of these lesions. One of the possible treatments for hemangiomas is the intralesional application of sclerosing agents to induce fibrosis of the vessels and regression of the lesions. The goal of this study was to report 4 cases of intraoral hemangiomas that occurred at different locations and produced satisfactory results with the application of Ethamolin. The clinical features, treatment protocols, and follow-up of the cases are discussed.