Sclerosing stromal tumor of the ovaries overexpressing vascular endothelial growth factor: two cases

Abstract

Sclerosing stromal tumor (SST) is histologically benign and accounts for 6% of the tumors derived from the stroma of the ovaries [1]. The patients who are diagnosed with an SST are predominantly in their 20s and 30s, unlike other stromal tumors [2,3]. Clinical imaging by magnetic resonance imaging (MRI) shows high vascularity and a solid part in SSTs. Many cases are suspected as a malignant tumor before surgery, during which, a unilateral ovary is removed without partial preservation. Case 1: A 25-year-old woman, gravida 0, para 0 who reported that she had never had sexual intercourse was admitted with the complaint of irregular and frequent menstruation every 15e30 days. A 10-cm-diameter pelvic mass at the front of the uterus was revealed by transrectal ultrasonography. MRI showed findings suggesting a possible malignant tumor in the right ovary (Figure 1). Gastroscopy and colon fiberoscopy were normal. Enhanced computed tomography showed no enlarged pelvic or para-aortic lymph nodes and no metastasis. The findings related to tumor markers [carbohydrate antigen (CA)-125, CA19-9, CA72-4, and human chorionic gonadotropin) and a hormonal analysis was within normal limits. A right salpingo-oophorectomywasperformedbecause the lesion wasmostly a solid tumor, but edematouswithyellowisheclear liquid (Figure 1). A fresh specimen from the solid part was used to obtain a frozen section, and massive ovarian edema was diagnosed.