Abstract
The endosomal sorting complex required for transport (ESCRT) proteins drive membrane scission of various biological processes such as multivesicular body biogenesis, autophagosome closure, and cytokinesis. The downstream ESCRT-III proteins are responsible for membrane constriction that leads to scission. Recruitment of spastin and VPS4, members of the AAA+ ATPase family, by ESCRTs promote fission; however, its exact role in this process is still unknown. In particular, if recruitment of spastin serves as an ESCRT localized microtubule (MT) severing enzyme or whether it plays a direct role in ESCRT disassembly.
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