Abstract
Microbeam radiation therapy (MRT) is an experimental technique delivering an array of high dose synchrotron X-ray microbeams. Development of metrics to predict the biological efficacy of MRT dose distributions is needed to guide further MRT research and for potential translation to human trials. The most commonly used metric is the peak-to-valley-dose ratio (PVDR) relating the dose at the microbeam center to that between two microbeams. We investigate three additional metrics that characterize dose distributions from a more volumetric perspective - the peak-to-mean-valley-dose ratio (PMVDR), mean dose, and percentage volume below a threshold. The metrics are evaluated for Monte Carlo simulations of dose distributions in three cubic head phantoms (2, 4 and 8 cm side lengths) for microbeam widths of 25, 50, and 75 μm and centre-to-centre spacings of 100, 200 and 400 μm. The ratio of the PMVDR to the PVDR varied from 0.24 to 0.80 for the different configurations, indicating a difference in the predicted geometric dependence of outcome for these two metrics. The mean dose was 102, 79, and 42 % of the mean skin dose for the 2, 8, and 16 cm head phantoms, respectively. The percentage volume below a 10% dose threshold was highly dependent on geometry, with ranges for the different collimation configurations of 2 - 87% and 33 - 96% for the 2 and 16 cm heads, respectively. Different dose-volume metrics exhibit different dependencies on MRT geometry parameters, suggesting that reliance on PVDR as a predictor of therapeutic outcome may be insufficient.
Published Version
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